摘要 目的：本研究观察GALLE-DONAU（加诺）对原发性高胆固醇血症患者的治疗作用和安全性。方法：采用患者自身对照的临床设计，42例原发性高胆固醇血症患者进行为期8周的加诺片口服治疗。第4、8周检测总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、甘油三酯(TG)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)、尿素氮(BUN)、肌酐(CREA)、空腹血糖(GLU)。结果：服药第8周TC 28.3%，LDL-C 35.51%，较服药前明显降低（P值均<0.00）；HDL-C和TG变化不明显。未见明显毒副作用。结论：GALLE-DONAU（加诺）能够明显降低TC、LDL-C，可以考虑作为治疗原发性高胆固醇血症的药物。
[外文]Effects of GALLE-DONAU on patients with original hyperlipaemia
Abstract Objective: To observe the effect and security of the GALLE-DONAU on treating patients with original hyperlipidemic.Method: According as the design of self-contrast, 42 patients with original hyperlipidemic had been treated with the GALLE-DONAU for 8 weeks. At the end of 4 and 8 weeks, tests were conducted on TC, LDC-C, HDC-C, TG, ALT, AST, TBIK, DBIL, IBIT, BUN,CREA and GLU.Result: After 8 weeks treatment, the content of TC（28.3%）and LDL-C(35.51%) in blood were significantly lower than that of before the treatment. And there was no significant differences on HDL-C and TG. And there was no evidently noxious and side effect during the experiment.Conclusion: The GALLE-DONAU can significantly reduce the content of TC and LDL-C in blood, and it can be consider as an effective medicine to treat patients with original hyperlipidemic.
Key words: GALLE-DONAU，hyperlipaemia